{"@context":["https://w3id.org/fdo/context/v1",{"schema":"https://schema.org/","prov":"http://www.w3.org/ns/prov#","fdo":"https://w3id.org/fdo/vocabulary/"}],"@id":"https://fdo.portal.mardi4nfdi.de/fdo/Q515404","@type":"DigitalObject","kernel":{"@id":"https://fdo.portal.mardi4nfdi.de/fdo/Q515404","digitalObjectType":"https://schema.org/ScholarlyArticle","primaryIdentifier":"mardi:Q515404","kernelVersion":"v1","immutable":true,"modified":"2026-03-23T18:23:09Z"},"profile":{"@context":"https://schema.org","@type":"ScholarlyArticle","@id":"https://portal.mardi4nfdi.de/entity/Q515404","name":"Optimal control and treatment of infectious diseases. The case of huge treatment costs","headline":"Optimal control and treatment of infectious diseases. The case of huge treatment costs","description":"scientific article; zbMATH DE number 6695440","url":"https://portal.mardi4nfdi.de/entity/Q515404","datePublished":"2017-03-16","author":[{"@id":"https://portal.mardi4nfdi.de/entity/Q515403"}],"publisher":[{"@id":"https://portal.mardi4nfdi.de/entity/Q61563"}],"identifier":{"@type":"PropertyValue","propertyID":"doi","value":"10.3390/MATH4020021","url":"https://doi.org/10.3390/MATH4020021"},"sameAs":["https://doi.org/10.3390/MATH4020021"],"comment":"Summary: The representation of the cost of a therapy is a key element in the formulation of the optimal control problem for the treatment of infectious diseases. The cost of the treatment is usually modeled by a function of the price and quantity of drugs administered; this function should be the cost as subjectively perceived by the decision-maker. Nevertheless, in literature, the choice of the cost function is often simply done to make the problem more tractable. A specific problem is also given by very expensive therapies in the presence of a very high number of patients to be treated. Firstly, we investigate the optimal treatment of infectious diseases in the simplest case of a two-class population (susceptible and infectious people) and compare the results coming from five different shapes of cost functions. Finally, a model for the treatment of the HCV virus using the \\textit{blowing-up cost function} is investigated. Some numerical simulations are also given.","citation":[{"@id":"https://portal.mardi4nfdi.de/entity/Q4693712"},{"@id":"https://portal.mardi4nfdi.de/entity/Q2935206"},{"@id":"https://portal.mardi4nfdi.de/entity/Q953700"},{"@id":"https://portal.mardi4nfdi.de/entity/Q404827"},{"@id":"https://portal.mardi4nfdi.de/entity/Q1625867"},{"@id":"https://portal.mardi4nfdi.de/entity/Q2441597"},{"@id":"https://portal.mardi4nfdi.de/entity/Q509205"},{"@id":"https://portal.mardi4nfdi.de/entity/Q420032"},{"@id":"https://portal.mardi4nfdi.de/entity/Q494492"},{"@id":"https://portal.mardi4nfdi.de/entity/Q611102"},{"@id":"https://portal.mardi4nfdi.de/entity/Q2479352"},{"@id":"https://portal.mardi4nfdi.de/entity/Q2922099"}]},"provenance":{"prov:generatedAtTime":"2026-03-23T18:23:09Z","prov:wasAttributedTo":"MaRDI Knowledge Graph"}}